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2000 1
2005 3
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2007 3
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2013 3
2014 3
2015 1
2017 3
2018 5
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2020 5
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2023 4
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40 results

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Page 1
Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?
Diallo K, Oppong AK, Lim GE. Diallo K, et al. Pharmacol Res. 2019 Jan;139:199-206. doi: 10.1016/j.phrs.2018.11.021. Epub 2018 Nov 16. Pharmacol Res. 2019. PMID: 30453034 Review.
Since their initial characterization as abundant brain proteins more than 5 decades ago, a resurgence into understanding the cellular functions of 14-3-3 proteins has emerged. ...Moreover, increasing lines of evidence demonstrate links between changes in 14-3-3 protein fun …
Since their initial characterization as abundant brain proteins more than 5 decades ago, a resurgence into understanding the cellular …
Biophysical and structural insight into the USP8/14-3-3 interaction.
Centorrino F, Ballone A, Wolter M, Ottmann C. Centorrino F, et al. FEBS Lett. 2018 Apr;592(7):1211-1220. doi: 10.1002/1873-3468.13017. Epub 2018 Mar 2. FEBS Lett. 2018. PMID: 29473952 Free article.
Here we report the high-resolution crystal structure of the 14-3-3 binding motif of USP8 surrounding Ser718 in complex with 14-3-3zeta and characterize the interaction with fluorescence polarization and isothermal titration calorimetry. ...
Here we report the high-resolution crystal structure of the 14-3-3 binding motif of USP8 surrounding Ser718 in complex with 14-3 …
Down-regulation of 14-3-3zeta reduces proliferation and increases apoptosis in human glioblastoma.
Yang X, Cao W, Wang X, Zhang X, Zhang W, Li Z, Fu H. Yang X, et al. Cancer Gene Ther. 2020 Jun;27(6):399-411. doi: 10.1038/s41417-019-0097-7. Epub 2019 May 9. Cancer Gene Ther. 2020. PMID: 31068674
Moreover, 14-3-3zeta was positively expressed in glioblastoma stem cells. Our data highlight the importance of 14-3-3zeta in glioblastoma and identify 14-3-3zeta as a potential molecular target for glioblastoma treatm …
Moreover, 14-3-3zeta was positively expressed in glioblastoma stem cells. Our data highlight the importance of 14 …
14-3-3zeta Participates in the Phase Separation of Phosphorylated and Glycated Tau and Modulates the Physiological and Pathological Functions of Tau.
Liu YQ, Liang CQ, Chen ZW, Hu J, Hu JJ, Luo YY, Chen YX, Li YM. Liu YQ, et al. ACS Chem Neurosci. 2023 Apr 5;14(7):1220-1225. doi: 10.1021/acschemneuro.3c00034. Epub 2023 Mar 20. ACS Chem Neurosci. 2023. PMID: 36939323
Regulating Tau phase separation helps maintain physiological functions of Tau and inhibits pathological aggregation. Here, we show that the 14-3-3 zeta isoform (14-3-3zeta) participates in Tau LLPS. 14-3-3zeta can undergo co-phase separat …
Regulating Tau phase separation helps maintain physiological functions of Tau and inhibits pathological aggregation. Here, we show that the …
14-3-3zeta promotes gliomas cells invasion by regulating Snail through the PI3K/AKT signaling.
Li J, Xu H, Wang Q, Wang S, Xiong N. Li J, et al. Cancer Med. 2019 Feb;8(2):783-794. doi: 10.1002/cam4.1950. Epub 2019 Jan 18. Cancer Med. 2019. PMID: 30656845 Free PMC article. Retracted.
14-3-3zeta has been reported to function as critical regulators of diverse cellular responses. However, the role of 14-3-3zeta in gliomas progression remains largely unknown. The expression level of 14-3-3zeta and Sna …
14-3-3zeta has been reported to function as critical regulators of diverse cellular responses. However, the role of …
miR-451a Regulates Neuronal Apoptosis by Modulating 14-3-3zeta-JNK Axis upon Flaviviral Infection.
Chakraborty S, Basu A. Chakraborty S, et al. mSphere. 2022 Aug 31;7(4):e0020822. doi: 10.1128/msphere.00208-22. Epub 2022 Jun 21. mSphere. 2022. PMID: 35727063 Free PMC article.
Upon its upregulation, miR-451a has been demonstrated to target 3'-UTR of 14-3-3zeta transcript culminating into downregulation of 14-3-3zeta at the protein level. ...The 14-3-3zeta transcript upon being targeted by m …
Upon its upregulation, miR-451a has been demonstrated to target 3'-UTR of 14-3-3zeta transcript culminating into downre …
Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14-3-3zeta.
Chen Y, Huang J, Liu J, Zhu H, Li X, Wen J, Tian M, Ren J, Zhou L, Yang Q. Chen Y, et al. Mol Neurobiol. 2023 Aug;60(8):4795-4810. doi: 10.1007/s12035-023-03378-9. Epub 2023 May 10. Mol Neurobiol. 2023. PMID: 37162725
Sirt1 overexpression inhibited fibroblast migration, proliferation, transdifferentiation into myofibroblasts, and secretion of extracellular matrix(ECM) by regulating the deacetylation of lysine at K49 and K120 sites of 14-3-3zeta in vitro. Therefore, we beli …
Sirt1 overexpression inhibited fibroblast migration, proliferation, transdifferentiation into myofibroblasts, and secretion of extracellular …
Relationship of 14-3-3zeta (zeta), HIF-1alpha, and VEGF expression in human brain gliomas.
Cao WD, Kawai N, Miyake K, Zhang X, Fei Z, Tamiya T. Cao WD, et al. Brain Tumor Pathol. 2014 Jan;31(1):1-10. doi: 10.1007/s10014-013-0135-3. Epub 2013 Jan 29. Brain Tumor Pathol. 2014. PMID: 23358800

The IRS of 14-3-3zeta increased with tumor grade, with grade IV gliomas having the highest score (P < 0.05). ...A significant positive correlation was found between the IRSs of 14-3-3zeta and HIF-1alpha, 14-3-3zeta

…

The IRS of 14-3-3zeta increased with tumor grade, with grade IV gliomas having the highest score (P < 0.05). ...A si

…
Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.
Brennan GP, Jimenez-Mateos EM, McKiernan RC, Engel T, Tzivion G, Henshall DC. Brennan GP, et al. PLoS One. 2013;8(1):e54491. doi: 10.1371/journal.pone.0054491. Epub 2013 Jan 24. PLoS One. 2013. PMID: 23359526 Free PMC article.
These studies demonstrate that increased 14-3-3zeta levels protect against ER stress and seizure-damage despite down-regulation of the unfolded protein response. Delivery of 14-3-3zeta may protect against pathologic changes resulting from …
These studies demonstrate that increased 14-3-3zeta levels protect against ER stress and seizure-damage despite down-re …
Formation of amyloid fibrils by the regulatory 14-3-3zeta protein.
Šulskis D, Žiaunys M, Sakalauskas A, Sniečkutė R, Smirnovas V. Šulskis D, et al. Open Biol. 2024 Jan;14(1):230285. doi: 10.1098/rsob.230285. Epub 2024 Jan 17. Open Biol. 2024. PMID: 38228169 Free PMC article.
Most importantly, they play an important role in various neurodegenerative disorders due to their vast interaction partners. Particularly, the 14-3-3zeta isoform is known to co-localize in aggregation tangles in both Alzheimer's and Parkinson's diseases …
Most importantly, they play an important role in various neurodegenerative disorders due to their vast interaction partners. Particularly, t …
40 results